Why the study?
Does indomethacin pretreatment alter the blood pressure and renin-angiotensin system response to an angiotensin II analogue in patients with Bartter's syndrome?
Does indomethacin pretreatment alter the blood pressure and renin-angiotensin system response to an angiotensin II analogue in patients with Bartter's syndrome?
Elevated levels of endogenous angiotensin II are of major importance for the maintenance of blood pressure in patients with Bartter's syndrome, and prostaglandin synthesis inhibition reverses some of its metabolic abnormalities.
Answers are grounded in this paper and cite their sources.
Prostaglandin inhibition may alter angiotensin II responses in Bartter syndrome; hypothesis-generating and should not yet change practice.
This study reports on the influence of indomethacin upon the renin--angiotensin system in three patients with Bartter's syndrome. An analogue of angiotensin II with weak agonistic properties (succinamyl1-val5-phenylglycine-acetate8-angiotensin II) induced a fall of blood pressure and a rise of plasma renin concentration but no change in plasma aldosterone. Pretreatment with indomethacin (75 mg/day) reversed the hypotensive effect of the analogue of angiotensin II and abolished the increase of plasma renin concentration. It is concluded that elevated levels of endogenous angiotensin II are of major importance for the maintenance of blood pressure in patients with Bartter's syndrome. The inhibition of the synthesis of prostaglandins reversed some, though not all, of the metabolic abnormalities in this syndrome.
No takes yet. Share an insight, caveat, or question.
Vierhapper et al. (1980) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: