Key result
Oral indomethacin decreased blood pressure and normalized all biochemical abnormalities in two siblings with renin-dependent hypertension, hyperaldosteronism, and hypokalemia.
Why the study?
Does oral indomethacin improve blood pressure and biochemical abnormalities in patients with renin-dependent hypertension, hyperaldosteronism, and hypokalemia?
Case Report (n=2)
Does oral indomethacin improve blood pressure and biochemical abnormalities in patients with renin-dependent hypertension, hyperaldosteronism, and hypokalemia?
In two siblings with renin-dependent hypertension and hyperaldosteronism, indomethacin normalized blood pressure and biochemical abnormalities, suggesting a state of hyperprostaglandinism secondary to hypertension with increased sympathetic tone.
Answers are grounded in this paper and cite their sources.
Indomethacin may normalize BP and labs in rare renin-dependent hypertension; leaves open confirmation and mechanism in prospective studies.
Two siblings are described with hypertension, hyperreninism, hyperaldosteronism and hypokalemia. Propranolol therapy lowered blood pressure markedly, but failed to normalize serum potassium. Indomethacin orally decreased blood pressure and normalized all biochemical abnormalities. We suggest that in these patients there exists a renin-dependent hypertension in combination with a state of hyperprostaglandinism. It is likely from our studies in these 2 patients, that the state of hyperprostaglandinism is secondary to a hypertension with increased sympathetic tone.
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Jong et al. (2008) conducted a case report in Renin-dependent hypertension, hyperaldosteronism and hypokalemia (n=2). Indomethacin vs. Propranolol was evaluated on Blood pressure and biochemical abnormalities. Oral indomethacin decreased blood pressure and normalized all biochemical abnormalities in two siblings with renin-dependent hypertension, hyperaldosteronism, and hypokalemia.
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