Key result
Indomethacin markedly suppresses active renin and raises blood pressure to control values during sequential therapy.
Why the study?
The study aimed to characterize acid-activated renin responses to hydrochlorothiazide, propranolol, and indomethacin in essential hypertensive patients.
How do hydrochlorothiazide, propranolol, and indomethacin affect acid-activated renin responses and blood pressure in essential hypertensive patients?
Population
6 essential hypertensive patients (five with low renin)
Design
Sequential weekly treatment case series
Follow-up
Successive weeks
Authors
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Indomethacin may raise BP via renin suppression in essential hypertension; hypothesis-generating for prostaglandin mechanisms and requires confirmation.
How do hydrochlorothiazide, propranolol, and indomethacin affect acid-activated renin responses and blood pressure in essential hypertensive patients?
Indomethacin suppresses diuretic-stimulated active renin release and increases blood pressure in essential hypertensive patients, highlighting the role of prostaglandins in renin regulation.
McKenzie et al. (1978) studied Essential hypertension (n=6). Hydrochlorothiazide, propranolol, and indomethacin vs. Placebo was evaluated on Renin responses (active and inactive), blood pressure, and serum aldosterone. Sequential treatment with hydrochlorothiazide, propranolol, and indomethacin showed that indomethacin markedly suppressed active renin and raised blood pressure to control values.
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