Why the study?
Do captopril, propranolol, and indomethacin affect blood pressure and plasma renin activity in spontaneously hypertensive and normotensive rats?
Population
Spontaneously hypertensive (SHR) and normotensive rats (NTR)
Design
Preclinical
Authors
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Sympathetic mediation of captopril PRA effects suggested in rats; leaves open translation to human hypertension therapy.
Do captopril, propranolol, and indomethacin affect blood pressure and plasma renin activity in spontaneously hypertensive and normotensive rats?
The increase in plasma renin activity caused by captopril in spontaneously hypertensive rats is likely reflexly mediated by compensatory sympathetic activation.
Antonaccio et al. (1979) studied this question.
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