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January 1, 1980Clinical and experimental hypertension

Single-Dose Captopril Administration in DOCA/Salt Rats: Reduction of Hypotensive Effect by Indomethacin

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Why the study?

Does indomethacin attenuate the hypotensive effect of captopril in DOCA/salt hypertensive rats?

Population

Deoxycorticosterone-salt (DOCA/salt) hypertensive rats and normotensive control rats

Comparison

Captopril 1 mg/kg intraperitoneal injection… vs Normotensive control rats

Design

Preclinical

Authors

IMIsamu MiyamoriMBM. J. BrownCDC. T. Dollery

Discussion

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Overview

Indomethacin attenuates captopril hypotension in this rat model; leaves open prostaglandin mediation of ACE inhibitors in clinical hypertension.

Structured PICO

Does indomethacin attenuate the hypotensive effect of captopril in DOCA/salt hypertensive rats?

P
Population
Deoxycorticosterone-salt (DOCA/salt) hypertensive rats and normotensive control rats
I
Intervention
Captopril 1 mg/kg intraperitoneal injection, with or without indomethacin 2.5 mg/kg intraperitoneal pretreatment
C
Comparator
Normotensive control rats
O
Outcome
Systolic blood pressure and plasma renin activity (PRA)surrogate

The hypotensive effect of captopril in DOCA/salt hypertensive rats is attenuated by indomethacin, suggesting the blood pressure lowering effect may be partially mediated by prostaglandins.

Cite This Study

Miyamori et al. (1980) studied this question.

synapsesocial.com/papers/6a1cc8d5732133fe9885e27bhttps://doi.org/10.3109/10641968009037152
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