Assessment of the effect of paclitaxel-prednisolone -maropitant neo adjuvant chemotherapy on metastatic pulmonary lesions associated with canine mammary tumours using thoracic radiography

Canine mammary tumours associated with pulmonary metastasis assume significant treatment challenges in dogs due to limited protocols and reduced surgical suitability. This study evaluated the therapeutic effects of a neoadjuvant chemotherapy protocol using a dose-dense protocol involving paclitaxel, prednisolone and maropitant in eight dogs. Treatment response was evaluated by monitoring changes in tumour volume and by assessing changes in metastatic lesions through thoracic radiography. Assessment of the protocol based on tumour volume revealed only partial response. Various pulmonary metastatic lesions including fine miliary nodules, pulmonary micronodules, nodules and masses were identified. These lesions showed diverse radiographic outcomes following therapy, such as complete disappearance of select nodules, reduction in size or stabilisation without further progression. Findings in this study suggest potential benefit in selected cases and support longer-duration protocols for improved outcomes.