Key result
Osteoporosis is linked to ~78% higher odds of MI in men aged ≥40 years.
Why the study?
Osteoporosis and myocardial infarction share upstream predisposing factors and substantial morbidity, but population-level estimates of their association remain limited, particularly in men.
Is there an association between self-reported physician-diagnosed osteoporosis and prior myocardial infarction in postmenopausal women and men aged 40 years or older?
Cross-Sectional (n=11,824)
Yes
Is there an association between self-reported physician-diagnosed osteoporosis and prior myocardial infarction in postmenopausal women and men aged 40 years or older?
Answers are grounded in this paper and cite their sources.
This nationally representative cross-sectional analysis demonstrates a significant bidirectional statistical association between self-reported osteoporosis and prior myocardial infarction in men aged >=40 years and a positive non-significant trend in postmenopausal women, supporting coordinated cardiovascular and skeletal risk assessments in primary care.
IntroductionOsteoporosis and myocardial infarction (MI) share upstream predisposing factors and substantial morbidity, but population-level estimates of their association remain limited, particularly in men. MethodsThis study performed an analysis of self-reported physician-diagnosed osteoporosis and MI through a survey-weighted logistic regression of five National Health and Nutrition Examination Survey (NHANES) cycles: 2005-2006, 2007-2008, 2009-2010, 2013-2014, and 2017-2018, cycles for which the osteoporosis data were available.The analysis was performed with osteoporosis as the exposure and MI as the outcome for Model 1 and MI as the exposure and osteoporosis as the outcome for Model 2. Sex stratified cohorts of postmenopausal women (PMW) and men aged 40 years or greater were analyzed, with fasting and pharmacologic subsamples. ResultsA total of 16 logistic regressions were performed, finding a statistically significant association in the primary analysis in both directions for men, whereas the association trended positively but did not reach statistical significance in post menopausal women.Combined or sole adjustment for lipids or pharmacologic agents attenuated PMW and men cohort findings towards the null, in all but Model 2 in men adjusted for pharmacologic agents, which was statistically significant. ConclusionsThe logistic regression demonstrated a statistically significant association between self-reported osteoporosis and MI in men, alongside a positive but non-significant trend in PMW.Although this analysis did not directly measure or demonstrate specific biological pathways, this observed epidemiological link is consistent with previously proposed shared risk factor models.Prior literature hypothesizes that these conditions may be mediated through mechanisms such as estrogen deficiency, dyslipidemia, inflammation, and the receptor activator of nuclear factor-κB (RANK)-osteoprotegerin axis.With this observed statistical association, coordination of cardiovascular and skeletal risk assessments remains clinically prudent.
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Smith et al. (2026) conducted a cross-sectional in Osteoporosis and Myocardial Infarction (n=11,824). Self-reported physician-diagnosed osteoporosis vs. No self-reported osteoporosis was evaluated on Self-reported physician-diagnosed myocardial infarction in men aged ≥40 years (Model 1) (OR 1.78, 95% CI 1.10-2.89, p=0.019). Self-reported osteoporosis was associated with higher odds of myocardial infarction in men aged ≥40 years, but not in postmenopausal women.
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