Key result
Novel 8F basket-tip pulsed-field catheter enables high-density mapping and lesion prediction in preclinical testing.
Why the study?
Extending large-area focal PFA catheters beyond PVI to linear lesions requires electroanatomical mapping with the ablation catheter to avoid catheter exchanges associated with silent cerebral events and to reliably visualize lesion location.
This pilot preclinical study evaluates a novel basket-tip focal pulsed-field ablation catheter capable of integrated high-density electroanatomical mapping and lesion prediction without requiring catheter exchanges.
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Feasibility of integrated mapping-PFA in swine may reduce exchanges; hypothesis-generating for clinical translation.
Large-area focal pulsed-field ablation (PFA) catheters extend PFA beyond pulmonary vein isolation (PVI) to linear lesions.1 This requires electroanatomical mapping (EAM) with the ablation catheter, which avoids catheter exchanges associated with silent cerebral events,2 and adds versatility and reliable visualization of lesion location. We evaluated these aspects in a pilot chronic porcine study of an investigational 8F basket-tip catheter (FARAFLEX, Boston Scientific, Marlborough, MA, USA) with 19 mapping mini-electrodes, integrated into a 3D mapping system (OPAL HDx, Boston Scientific) and capable of monopolar or bipolar delivery.
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Kueffer et al. (2026) studied Porcine preclinical model for cardiac pulsed-field ablation and electroanatomical mapping. 8F basket-tip large-area focal pulsed-field ablation catheter with 19 mapping mini-electrodes integrated into a 3D mapping system was evaluated on Combined high-density electroanatomical mapping and lesion prediction. An investigational 8F basket-tip pulsed-field ablation catheter with 19 mini-electrodes was evaluated for high-density mapping and lesion prediction in a chronic porcine study.
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