Key result
Perioperative genomic profiling emerges as a promising tool to predict postoperative cardiovascular events.
Why the study?
Researchers are just beginning to unravel the genetic and molecular determinants that predispose surgical patients to an increased risk for postoperative cardiovascular adverse events.
This review discusses the emerging field of perioperative genomics and its potential to improve cardiovascular risk assessment and clinical management in surgical patients.
Answers are grounded in this paper and cite their sources.
Perioperative genomics remains exploratory for cardiovascular risk assessment; leaves open whether molecular profiling refines postoperative event prediction.
Considerable progress has been made in understanding the pathophysiology of perioperative stress responses and their impact on the cardiovascular system; however, researchers are just beginning to unravel genetic and molecular determinants that predispose to increased risk for postoperative cardiovascular adverse events. A new field, coined perioperative genomics, aims to apply functional genomic approaches to uncover the biological reasons why similar patients can have dramatically different clinical outcomes after surgery. For the perioperative physician, such findings may soon translate into prospective risk assessment incorporating genomic profiling of markers important in inflammatory, thrombotic, vascular, and neurologic responses to perioperative stress, with implications ranging from individualized additional pre-operative testing and physiological optimization, to perioperative decision-making, choice of monitoring strategies, and critical care resource utilization. We review current knowledge regarding genomic technologies in perioperative cardiovascular disease characterization and outcome prediction, as well as discuss future trends/challenges for translating integrated "omic" information into daily clinical management of the surgical patient.
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Podgoreanu et al. (2005) conducted a review in Perioperative cardiovascular disease. Perioperative genomic profiling was evaluated on Postoperative cardiovascular adverse events. Perioperative genomic profiling is reviewed as an emerging strategy to characterize perioperative cardiovascular disease and predict postoperative adverse events (no quantitative data reported).
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