Key result
Multiple sclerosis is linked to higher carotid-femoral pulse wave velocity independent of aerobic fitness.
Why the study?
Vascular function is worse in persons with multiple sclerosis than in healthy controls, and whether differences in aerobic fitness account for these group differences in arterial stiffness was uncertain.
Does aerobic fitness account for differences in arterial stiffness (cfPWV and AIx75) between persons with multiple sclerosis and healthy controls?
Cross-Sectional
Does aerobic fitness account for differences in arterial stiffness (cfPWV and AIx75) between persons with multiple sclerosis and healthy controls?
Increased arterial stiffness (cfPWV) in persons with multiple sclerosis persists after controlling for aerobic fitness, suggesting it may reflect underlying MS pathophysiology rather than deconditioning alone.
Answers are grounded in this paper and cite their sources.
Elevated arterial stiffness in MS may reflect pathophysiology beyond deconditioning; hypothesis-generating for CV implications and requires longitudinal validation.
Vascular function is worse in multiple sclerosis (MS) than healthy controls perhaps based on differences in aerobic fitness. We compared carotid-femoral pulse wave velocity (cfPWV) and augmentation index (AIx75) between MS and controls while accounting for aerobic fitness. Aerobic fitness was measured as peak oxygen consumption on a recumbent stepper. cfPWV and AIx75 were measured using applanation tonometry. Persons with MS demonstrated lower aerobic fitness and higher cfPWV, but no difference in AIx75 compared with controls. The difference in cfPWV remained statistically significant after controlling for aerobic fitness, suggesting that arterial stiffness might reflect underlying pathophysiology processes of MS.
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DeJonge et al. (2023) conducted a cross-sectional in Multiple sclerosis. Multiple sclerosis vs. Healthy controls was evaluated on Carotid-femoral pulse wave velocity (cfPWV) and augmentation index (AIx75). Multiple sclerosis was associated with significantly higher carotid-femoral pulse wave velocity compared with healthy controls even after controlling for aerobic fitness.
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