Efficacy of Non-Invasive Technological Regenerative Aesthetic Medicine for the Face and Neck: A Cohort Study

Background: Combined high-intensity focused ultrasound (HIFU) and dynamic quadripolar radiofrequency (DQRF) represent non-invasive energy-based technologies increasingly used in facial and neck rejuvenation. These approaches aim to improve skin laxity, wrinkles, and overall skin quality by stimulating dermal remodeling and neocollagenesis, while minimizing downtime and adverse effects. Given the multifactorial nature of facial aging, the need for standardized clinical evaluation of combined regenerative approaches remains relevant. Materials and Methods: This cohort study included 20 of the 28 patients initially enrolled, who successfully completed the combined HIFU and DQRF treatments according to a predefined protocol with multiple sessions and follow-up assessments over one year. Participants were stratified into three age groups (25–40, 41–55, 56–70 years). Outcomes were evaluated using validated patient-reported measures (FACE-Q, FLO-11, FLSQ, SGA, FTS) and standardized photographic analysis. Objective wrinkle and photoaging assessment was performed using validated scales including FWS, Fitzpatrick Wrinkle Classification, WAS, and Griffiths Photonumeric Scale. Safety and tolerability were also monitored throughout the study. Results: Overall, both subjective and objective outcomes showed consistent improvement across all age groups. The most pronounced clinical and patient-reported benefits were observed in the 41–55-year group, which showed the highest response across FACE-Q improvements and photographic score reductions. The 25–40-year group showed mild but consistent improvements, while the 56–70-year group exhibited moderate but less marked changes, despite higher baseline severity. Photographic analysis confirmed reductions in wrinkle depth and photoaging indices across all cohorts. Patient-reported outcomes indicated increased satisfaction, improved perceived facial freshness, and reduced wrinkle-related concerns. No clinically relevant adverse events were reported. Conclusions: The combined use of HIFU and DQRF appears to be a safe and potentially effective non-invasive approach for facial and neck rejuvenation, with an age-dependent response pattern favoring mid-age patients. Results support the role of energy-based regenerative technologies in aesthetic medicine, although further controlled studies with larger samples are required to confirm efficacy, optimize protocols, and refine patient selection.