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Primary pleural synovial sarcoma (PPSS) is an exceptionally rare and aggressive malignancy. We report a massive PPSS characterized by positive TLE1 immunostaining but negative SS18–SSX Fluorescence in situ hybridization (FISH). This case highlights the importance of integrating morphology, immunohistochemistry, and clinical context when molecular testing is inconclusive.
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Hou et al. (2026) studied this question.
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