Effects of Acute Aerobic Exercise Performed in a Single Supervised Cardiovascular Rehabilitation Session on Cardiovascular Disease Patients

Q: What is the clinical evidence from this study?

Population: Cardiovascular disease undergoing cardiac rehabilitation (n=71). Intervention: Single supervised cardiac rehabilitation session (acute aerobic exercise) vs. Baseline pre-exercise measurements (within-subject pre-post comparison). Primary outcome: Aortic pulsatility (cPP/cMAP) before vs. immediately after exercise (p=0.0465).

Q: What does this research mean for the field?

A single session of acute aerobic exercise in cardiac rehabilitation patients significantly reduces the reflection coefficient and aortic pulsatility without altering pulse wave velocity. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tamara Costábile Sant'Anna; Júlia Isaac Bernardes; Tiago Abreu Velloso; Janaíne Cunha Polese; Marcelo Tuesta; Maria da Glória Rodrigues‐Machado

doi:10.21203/rs.3.rs-8187705/v1

December 22, 2025Open Access

Effects of Acute Aerobic Exercise Performed in a Single Supervised Cardiovascular Rehabilitation Session on Cardiovascular Disease Patients

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Key result

A single cardiac rehabilitation session reduces reflection coefficient and aortic pulsatility without changing PWV.

P=0.0465
n=71

Why the study?

This study aimed to evaluate the effects of acute aerobic exercise in a single supervised cardiac rehabilitation session on cardiovascular parameters and their association with quality of life, functional capacity, and physical activity levels in patients with cardiovascular disease.

Does a single supervised session of acute aerobic exercise in cardiac rehabilitation alter central and peripheral blood pressure, hemodynamic parameters, and arterial stiffness indices in older adults with cardiovascular disease?

Key Points

To assess changes in cardiovascular parameters following a single supervised aerobic exercise session and examine associations between these parameters and functional capacity, physical activity levels, and quality of life.
Experimental study examining a convenience sample of 71 cardiac rehabilitation patients (mean age 75.14 ± 10.28 years; 59.15% male) undergoing rehabilitation for at least 6 months.
Cardiovascular and hemodynamic parameters were recorded before and after a single supervised exercise session using the Mobil-O-Graph device.
Quality of life, functional capacity, and physical activity levels were assessed using the SF-36, Duke Activity Status Index (DASI), and Human Activity Profile (HAP).
Systolic volume decreased from 69.92 ± 11.87 ml to 65.15 ± 15.17 ml (p = 0.0005) after exercise, alongside significant decreases in aortic pulsatility and reflection coefficient, while heart rate increased.
Peripheral systolic blood pressure (122.60 ± 15.84 vs. 122.10 ± 14.37 mmHg; p = 0.6773) and central systolic blood pressure (111.60 ± 14.79 vs. 110.00 ± 13.74 mmHg; p = 0.5918) did not differ significantly after exercise.
Pulse wave velocity correlated negatively with functional capacity on the DASI (r = -0.5387, p = 0.0001) and adjusted activity scores on the HAP (r = -0.4964, p = 0.0001).

Structured PICO

Does a single supervised session of acute aerobic exercise in cardiac rehabilitation alter central and peripheral blood pressure, hemodynamic parameters, and arterial stiffness indices in older adults with cardiovascular disease?

P

Population

71 older adults (mean age 75.14 years, 40.85% female) with cardiovascular diseases enrolled in a cardiac rehabilitation program for at least 6 months, evaluated before and immediately after a single 60-minute supervised exercise session.

I

Intervention

Single 60-minute supervised cardiac rehabilitation session consisting of a 15-minute dynamic warm-up, 15 minutes of dynamic lower-limb mat exercises, and 30 minutes of low-to-moderate intensity aerobic exercise on a treadmill and horizontal bicycle (50-70% heart rate reserve or modified Borg scale 2-4).

C

Comparator

Pre-exercise baseline measurements taken in a sitting position after 10 minutes of rest (single-group pre-post comparison).

O

Outcome

Cardiovascular parameters (peripheral and central blood pressure, hemodynamic variables including systolic volume and heart rate, arterial stiffness indices including pulse wave velocity, AIx@75, reflection coefficient, and aortic pulsatility [cPP/cMAP]) measured via Mobil-O-Graph immediately before and after the exercise session.surrogate

Main Result

Absolute Event Rate: 0.39% vs 0.4%

p-value: p=0.0465

A single supervised cardiac rehabilitation aerobic session acutely reduces wave reflection coefficient and aortic pulsatility in older patients with cardiovascular disease, while higher functional capacity and physical activity levels correlate with lower baseline arterial stiffness (PWV).

Limitations

Delay in post-exercise cardiovascular parameter collection in some situations due to technical complications in data acquisition
Convenience sample composed of patients undergoing cardiac rehabilitation for at least 6 months, limiting generalizability
Sample size too small to categorize patients by sex or specific cardiovascular disease category
Single-center study with a specific standardized cardiac rehabilitation protocol
Technical complications caused delays in immediate post-exercise data acquisition in some situations
Sample restricted to patients already in cardiac rehabilitation for at least 6 months, limiting generalizability
Sample size insufficient to stratify analyses by sex or specific cardiovascular disease category
Single-center study with a single standardized rehabilitation protocol

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Implication

May support acute hemodynamic effects in cardiac rehab; leaves open long-term arterial stiffness impact.

Abstract

Purpose To evaluate the effects of acute aerobic exercise in a supervised Cardiac Rehabilitation (CR) session on cardiovascular parameters. To verify the association between health-related factors (anthropometry, quality of life, functional capacity and physical activity level) and cardiovascular parameters. Methods This experimental study evaluates cardiovascular parameters before and after a single CR session using the Mobil-O-Graph®. Quality of life was assessed by SF-36. Functional capacity and physical activity level (PAL) were evaluated by Duke Activity Status Index (DASI) and Human Activity Profile (HAP), respectively. It was a convenience sample, composed of patients who participated in a CR program. Results 71 patients (75.14 ± 10.28 years) were included. Heart rate significantly increased and systolic volume decreased (p = 0.0005) after exercise. The reflection coefficient and aortic pulsatility decreased significantly after exercise. Pulse wave velocity (PWV) negatively correlated with DASI scores (r= -0.5387, p = 0.0001) and HAP [adjusted activity score (r= -0.4964, p = 0.0001) and maximum activity score (r= -0.2904, p = 0.0140)], physical functioning and physical limitation of SF-36 applied before the CR session. Mean arterial pressure, central systolic and diastolic blood pressure positively associated with the SF-36 General Health Status component. cDBP associated with DASI and adjusted activity score. Conclusion PWV negatively correlated with DASI and HAP scores, indicating that individuals with lower PALs present higher PWV. The reduction in aortic pulsatility after exercise suggests a protective effect on high-flow organs. CONDENSED ABSTRACT This study evaluated cardiovascular parameters before and after a single CR session; and verified the association of these parameters with quality-of-life (SF-36), functional capacity (DASI) and physical activity level (HAP) of individuals with cardiovascular diseases. Pulse wave velocity negatively correlated with DASI and HAP scores and aortic pulsatility reduced after exercising.

Discussion

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Cite This Study

Sant'Anna et al. (2025) studied Cardiovascular disease undergoing cardiac rehabilitation (n=71). Single supervised cardiac rehabilitation session (acute aerobic exercise) vs. Baseline pre-exercise measurements (within-subject pre-post comparison) was evaluated on Aortic pulsatility (cPP/cMAP) before vs. immediately after exercise (p=0.0465). Acute aerobic exercise in a single cardiac rehabilitation session reduced reflection coefficient and aortic pulsatility while pulse wave velocity remained unchanged.

synapsesocial.com/papers/6af742a4d8dede94de2efefd https://doi.org/10.21203/rs.3.rs-8187705/v1

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Effects of Acute Aerobic Exercise Performed in a Single Supervised Cardiovascular Rehabilitation Session on Cardiovascular Disease Patients

Key Points

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effects of Acute Aerobic Exercise Performed in a Single Supervised Cardiovascular Rehabilitation Session on Cardiovascular Disease Patients

Key Points

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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