Association between obesity-related indicators and peripheral neuropathy in type 2 diabetes mellitus

Objective This study investigated the association between obesity-related indices [Lipid Accumulation Product (LAP), Visceral Adipose Index (VAI), Body Roundness Index (BRI)] and diabetic peripheral neuropathy (DPN) in Chinese patients with type 2 diabetes mellitus. Methods 1098 participants with type 2 diabetes were enrolled. The correlation between and DPN as well as abnormal vibration perception threshold (VPT) were explored by logistic regression and multiple linear regression analysis. Results VAI was significantly correlated with higher likelihood of having DPN (OR 1.175, 95% CI 1.012–1.363, P = 0.034). LAP and VAI were associated with abnormal VPT (OR 1.024, 95%CI 1.011–1.038, P < 0.001 for LAP; OR 1.203, 95%CI 1.044–1.386, P = 0.011 for VAI). Multiple linear regression analysis showed that LAP and VAI were associated with VPT (LAP, β = 0.038, 95% CI 0.014–0.061, P = 0.002; VAI, β = 0.313, 95% CI 0.037–0.589, P = 0.026). Conclusions Our study shows that VAI was significantly associated with DPN, and LAP as well as VAI were significantly correlated with abnormal VPT in Chinese patients with type 2 diabetes.