Electrospun polyvinyl alcohol nanofibrous membranes incorporated with silver nanowires and sambiloto (andrographis paniculata nees) for wound healing applications

A new variation of wound covering nanofibrous membranes synthesized using electrospinning method from mixtures of polyvinyl alcohol (PVA), silver nanowires (AgNWs), and sambiloto (Andrographis paniculata Nees) leaves has successfully been developed for antibacterial applications. Four variations of nanofibrous membranes, namely pure PVA, PVA and sambiloto (PVA/S), PVA and silver nanowires (PVA/AgNWs), as well as PVA, sambiloto, and silver nanowires (PVA/S/AgNWs) were prepared and preclinically tested on white mice (Mus muscullus) that had previously been injured. The FTIR spectrum wavenumbers of PVA/S, PVA/AgNWs, and PVA/S/AgNWs for the (O-H) functional group experienced a shift greater (shifted left) than PVA. For the SEM images, the minimum diameter of the membrane nanofiber was 122 nm, while the maximum was 257 nm. The results showed that wound healing in the mice occurred after 72 h, while the PVA/S/AgNWs membranes demonstrated a more complete and accelerated wound closure than other membranes. Furthermore, the potential of sambiloto as an ingredient in a wound covering drug is relatively large. Sambiloto is an andrographolide compound used to fight disease due to its antibacterial power as well as the potential to activate lymphocytes and produce antibodies and silver has been used extensively in clinical equipment as an antimicrobial.