Exploring the Antibacterial Potential of Alcoholic Ginger Extract Against Key Gram-Negative Pathogens: E. Coli and Pseudomonas Aeruginosa

Ginger, scientifically known as Zingiber officinale, is a popular spice and medicinal plant used in various traditional and alternative medicine practices. While ginger has many potential health benefits, including anti-inflammatory and antioxidant properties, its effectiveness as an antibacterial agent is still a subject of ongoing research and debate. This study was conducted in order to determine the antibacterial activity of alcoholic ginger extract on some Gram-negative bacter. Obtaining ginger from the local market in Najaf City – Najaf Governorate – Iraq and bacterial isolates Pseudomonas aeruginosa and Escherichia coli Obtained From the Department of Biology- College of Science – University of Kufa and confirmed by cultural and biochemical examination and ultimately by VITEK-2 compact system . Four types of antibiotics were used to find out the bacteria’s resistance to these antibiotics, which are Meropenem, Imipenem , Ciprofloxacin and Gentamycin. The results showed Pseudomonas aeruginosa resistance to all antibiotics except for ciprofloxacin, which was sensitive to it, while Escherichia coli was sensitive to all antibiotics. Antibacterial activity of alcoholic ginger extract on Pseudomonas aeruginosa and Escherichia coli showed the inhibition zone , where the diameters of inhibition reached(20-16-14-11-0) mm for Pseudomonas aeruginosa while The diameters of the inhibition zone were (18-15-13-11-0) mm for Escherichia coli at the concentrations (1000,800,600,400,200) ug/ml, respectively, compared to the control group, which was not effective. The results of study indicate to the concentration 1000 ug/ml more effective on both types of bacteria from another concentrations.