Association of adiponectin receptor 2 (rs10773989) and IL-16 (rs4072111) gene variants with breast cancer susceptibility

The most common type of cancer in women is breast cancer. Adiponectin receptors are found in certain cancer cells, such as those in colorectal, breast, and prostate cancers. Interleukin 16 is involved in helping cancer cells grow and change. The aim of the study was to evaluate the association of adiponectin receptor-2 (ADIPOR2) (rs10773989) and interleukin -16 (IL-16) (rs4072111) gene variants with breast cancer susceptibility. In this case-control study, 156 participants were divided into three groups: 52 breast cancer (BC) patients, 52 breast adenoma patients, and 52 healthy volunteers who were matched for age and gender to serve as controls. ADIPOR2 (rs10773989) and IL-16 (rs4072111) gene variants were studied using real-time polymerase chain reaction (real-time PCR). Patients carrying the CC genotype of ADIPOR2 (rs10773989) had a 6-fold increased risk of BC (95% CI: 1.506-23.907, P = 0.006); in addition, patients carrying the C allele of ADIPOR2 (rs10773989) had a 2.9-fold increased risk of BC (95% CI: 1.544-5.489, P < 0.001). The study concluded that The ADIPOR2 (rs10773989) gene variant is significantly associated with BC, with the CC genotype and C allele conferring a more than twofold increased risk. This genetic variant in ADIPOR2 (rs10773989) may contribute to BC susceptibility and can serve as a potential genetic risk marker.