Key result
Ankylosing spondylitis linked to ~2-point lower global myocardial work efficiency versus healthy controls.
Why the study?
Does non-invasive myocardial work analysis detect subclinical left ventricular dysfunction in patients with ankylosing spondylitis compared to healthy controls?
Case-Control (n=94)
Does non-invasive myocardial work analysis detect subclinical left ventricular dysfunction in patients with ankylosing spondylitis compared to healthy controls?
Patients with ankylosing spondylitis exhibit increased LV mechanical dispersion and wasted myocardial work alongside reduced myocardial work efficiency that persist after adjusting for GLS, indicating complementary value for detecting subclinical LV dysfunction.
Answers are grounded in this paper and cite their sources.
Myocardial work analysis may complement GLS for subclinical LV dysfunction in ankylosing spondylitis; hypothesis-generating and requires prospective validation.
Objectives Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with increased cardiovascular risk. This study aimed to evaluate subclinical left ventricular (LV) dysfunction in patients with AS using non‐invasive myocardial work analysis. Methods 50 patients with AS and 44 age‐ and sex‐matched healthy controls were enrolled. Comprehensive clinical characteristics were documented for all participants. Two dimensional dynamic images of the apical four‐chamber, two chamber, and three‐chamber views were collected from all subjects, with three consecutive cardiac cycles recorded for each view. LV myocardial strain parameters, including global longitudinal strain (GLS) and peak strain dispersion (PSD), as well as myocardial work indices, including global work index (GWI), and global constructive work (GCW), global wasted work (GWW), global work efficiency (GWE), were obtained and subsequently analyzed. Results Compared with controls, patients with AS had lower absolute GLS (18.46±2.00% vs.19.41±1.91%, p = 0.021), higher PSD () and GWW ([106.00 (68.75–140.00) vs. 61.00 (49.25–81.25) mmHg%, P < 0.001), along with lower GWI(1679.26±226.70 vs. 1780.84±209.25 mmHg%, P < 0.05) and GWE (94.08±2.68% vs. 96.32±0.93%, P < 0.001). Furthermore, PSD was positively correlated with GWW ( r = 0.59, P < 0.001) and negatively correlated with GWE ( r = −0.65, P < 0.001). After adjustment for age, sex, systolic blood pressure, LV mass index, and GLS, AS remained associated with higher PSD (, higher GWW (, and lower GWE ( P < 0.001), whereas the associations with GWI and GCW were not statistically significant. Conclusions Patients with AS exhibited increased LV mechanical dispersion and wasted myocardial work and reduced myocardial work efficiency. These alterations persisted after adjustment for GLS, suggesting that PSD and myocardial work analysis may provide complementary information for characterizing subclinical LV dysfunction in AS.
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Tao et al. (2026) conducted a case-control in Ankylosing spondylitis (n=94). Ankylosing spondylitis vs. Age- and sex-matched healthy controls was evaluated on Global work efficiency (GWE) (p=<0.001). Ankylosing spondylitis was associated with reduced global work efficiency and higher global wasted work compared with healthy controls.
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