Antibacterial heterostructures of fullerenes and boron-containing nanoparticles

New methods for the synthesis of heterostructures combining oxidized boron in planar form (borophene-like) and fullerene C60 have been developed and the obtained nanoparticles (size ∼ 200 nm) were characterized by X-ray diffraction, UV-Vis optical absorption, Raman spectroscopy, dynamic light scattering. Following MTT tests on biological cells (Human skin fibroblasts) have demonstrated new preparations’ low toxicity when it decreased as a result of attachment of fullerenes to boron containing particles. At the same time, the particles with fullerene possessed a great ability to penetrate into tumor cells (human lung cancer cells, HeLa G63 – human cervical carcinoma cells) that is crucially important for the applications of new preparations in theranostics with using pieso(photo)dynamic methods. The heterostructures have revealed a high activity against highly pathogenic and conditionally pathogenic gram-positive and gram-negative bacteria and fungi (Staphylococcus aureus and Staphylococcus epidermidis, Escherichia coli, and Candida albicans and Bacillus subtilis) and significantly suppressed biofilm formation even at moderate doses.