Synthesis, Spectroscopic Characterization, and Evaluation of the Macromolecular Interaction of Hydrazone Derivatives as Potential Monomers for Coordination Polymers

This study reports the preparation and comprehensive characterization of a series of hydrazone compounds derived from hydrazide precursors. These compounds are of significant interest in macromolecular chemistry due to their potential to function as versatile monomers or oligomers in the formation of novel coordination polymers and supramolecular assemblies. The synthesized compounds were rigorously analyzed using a suite of spectroscopic techniques, including ultraviolet–visible spectroscopy, carbon nuclear magnetic resonance, proton nuclear magnetic resonance, and Fourier transform infrared spectroscopy, to confirm their structural authenticity and purity. Beyond their chemical characterization, the compounds were evaluated for their biological activity, specifically their inhibitory effect against the bacteria Pseudomonas aeruginosa and Staphylococcus aureus . This biological assessment is framed as an investigation into the macromolecular interaction between the synthesized organic molecules and the essential biopolymeric components of the bacterial cell wall and internal machinery. The findings provide a foundation for understanding the structure–activity relationship of these hydrazone derivatives, particularly in the context of designing new polymeric materials with inherent antimicrobial properties through targeted macromolecular binding.