The effect of an antihypoxic drug on blood parameters in patients with obstructive jaundice

Objective. To evaluate the efficacy of Reamberin, a balanced succinate-containing crystalloid solution, in the combination therapy of patients with non-neoplastic obstructive jaundice by analyzing the dynamics of peripheral blood counts. Methods. This prospective comparative study included 94 patients with non-neoplastic obstructive jaundice, divided into two groups: a study group (n=31) receiving Reamberin infusions as part of combination therapy, and a comparison group (n=63) undergoing traditional therapy. The following hematological parameters were assessed: red blood cell stability, mean corpuscular concentration (MCV), mean corpuscular hemoglobin (MCH), white blood cell stability, platelet stability, and mean platelet concentration (MPV). Student’s t-tests and SPSS 23 were used to evaluate statistical changes in laboratory data. Results. Statistically significant differences were found between the conclusions for a number of hematological parameters. In the study group, a more pronounced normalization of red blood cell parameters was observed, as well as significant changes in platelet and white blood cell parameters. The data obtained indicate positive dynamics in blood cell formation during antihypoxant therapy. Conclusion. The use of infusions of a complex solution of sodium meglumine succinate in patients with non-neoplastic obstructive jaundice is associated with an improvement in hematological parameters and correction of hemal hypoxia, confirming the pathogenetic rationale for including antihypoxants in combination therapy for this category of patients.