Macromolecular Interaction and Comparative Analysis of the Biopolymeric (Oxyntomodulin and Insulin) in the Metabolic Regulation of Obese Women

The findings highlight the significance of peptide and protein macromolecular signaling in obesity‐associated metabolic dysregulation, providing new insights into biomacromolecular mechanisms that may support the design of next‐generation peptide‐based therapeutic strategies for metabolic disorders. Oxyntomodulin, a peptide hormone, is currently under investigation for its potential positive effects on appetite regulation, metabolic improvement, and the promotion of fat catabolism. Insulin, a well‐characterized macromolecular protein hormone, is central to glucose homeostasis. The study aims to understand the relationship between the activity of the Oxyntomodulin macromolecule and the degree of obesity, as well as to analyze the effect of the Insulin macromolecule on the overall metabolic status in this patient cohort. By investigating the concentrations and presumed functional integrity of these two biopolymeric entities, the research seeks to elucidate the underlying biochemical mechanisms that contribute to the development and complications of obesity. Obese women exhibited significantly reduced oxyntomodulin (4.16 vs. 7.23 ng/mL) and elevated insulin (9.02 vs. 7.61 μIU/mL) levels ( p < 0.0001), demonstrating disrupted peptide–protein macromolecular signaling associated with obesity‐related metabolic dysfunction and supporting their potential as biomarkers and therapeutic targets.