Readily Fabricated Functionalized Flexible Electrode Arrays for Peel‐and‐Stick Electrophysiologic Monitoring

Wearable electrical sensors offer noninvasive, high‐fidelity monitoring of organ‐level electrophysiology. In gastrointestinal applications, electrogastrography (EGG) enables detection of gastric myoelectric activity from the skin surface. Previous work to collect high‐resolution EGG (HR‐EGG) data (at least 8 electrode channels) has involved systems that are bulky, prone to electrode placement variability, not amenable to industrial‐scale manufacturing, and/or unsuitable for ambulatory or unsupervised clinical usage. Here, a polyimide‐based flexible adhesive multi‐electrode array that addresses these gaps is presented, optimized for measuring gastric myoelectric activity in ambulatory settings. This design enables consistent inter‐electrode spacing, reduces user burden, and offers significant conformability improvements over rigid commercial multi‐electrode systems. Multiple electrode interface strategies—incorporating material systems of Ag/AgCl, PEDOT:PSS, and conductive hydrogel—are implemented to reduce electrode impedance, with characterization using electrochemical impedance spectroscopy. We further provide a comparative evaluation of functionalization strategies and equivalent circuit modeling of these systems, which can enable adapting this work for monitoring electrophysiology from other organs. This wearable is validated through 15 pre‐ and post‐meal recordings, showing reliable extraction of gastric activity, as well as further evaluation of the data to show repeatability within participants.