Left Atrial Appendage Aneurysm Presenting With Atrial Fibrillation in a Young Woman: A Case Report

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Left atrial appendage aneurysm (LAAA) presenting with atrial fibrillation and exertional dyspnea (n=1). Intervention: Complete surgical resection of left atrial appendage aneurysm via sternotomy, followed by warfarin and later catheter ablation. Primary outcome: Aneurysm exclusion, thromboembolic events, and arrhythmia recurrence.

Q: What does this research mean for the field?

Surgical resection of a left atrial appendage aneurysm prevents thromboembolism, although catheter ablation may be required to achieve sinus rhythm if atrial fibrillation persists. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Rezayat Parvizi; Shahla Meshgi; Mohammad Rostamzadeh; Sohrab Negargar; Eissa Bilehjani; Solmaz Fakhari; Amir Faravan

doi:10.1002/ccr3.73941

November 1, 2026Clinical Case ReportsOpen Access

Left Atrial Appendage Aneurysm Presenting With Atrial Fibrillation in a Young Woman: A Case Report

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Why the study?

Left atrial appendage aneurysm is a rare cardiac anomaly.

Key Points

Describe the diagnostic imaging, surgical management, and clinical course of a rare left atrial appendage aneurysm presenting with atrial fibrillation in a young adult.
Evaluated a 25-year-old woman presenting with exertional dyspnea, palpitations, and atrial fibrillation with a rapid ventricular response (heart rate approximately 120 bpm).
Conducted diagnostic evaluations including electrocardiography, chest radiography, and transthoracic echocardiography.
Performed surgical excision of the aneurysm via sternotomy without concomitant surgical rhythm control, followed by histopathology and post-discharge anticoagulation with warfarin.
Transthoracic echocardiography revealed a left atrial appendage aneurysm measuring approximately 63 × 31 mm without intracavitary thrombus, an LVEF of 50%, and a left atrial volume of 89 mL.
Histopathology confirmed a congenital aneurysm characterized by a thin-walled fibromuscular aneurysmal sac without malignancy, vasculitis, or organized thrombus.
At 6-month follow-up, the patient showed complete aneurysm exclusion with no thromboembolism or recurrence; persistent atrial fibrillation was subsequently converted to sinus rhythm with catheter ablation during the first postoperative year.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P

Population

1 young adult woman (age 25) with a large congenital left atrial appendage aneurysm (80 × 67 × 62 mm) presenting with atrial fibrillation and exertional dyspnea, followed for 1 year postoperatively.

I

Intervention

Complete surgical resection of the left atrial appendage aneurysm via sternotomy with double-layer closure of the aneurysmal neck (without concomitant Maze or surgical pulmonary-vein isolation), postoperative oral anticoagulation with warfarin, and subsequent catheter ablation within the first postoperative year.

O

Outcome

Complete exclusion of the aneurysm, absence of thromboembolic events, aneurysm recurrence, or hospital readmission at 6-month follow-up, and restoration of sinus rhythm within the first postoperative year.hard clinical

This case highlights that while surgical resection of a large left atrial appendage aneurysm effectively prevents thromboembolism and excludes the aneurysm, atrial fibrillation may persist due to underlying atrial remodeling and require subsequent catheter ablation.

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Implication

May support resection of large LAA aneurysms to prevent thromboembolism; hypothesis-generating and should not yet change practice.

Abstract

Left atrial appendage aneurysm (LAAA) is a rare cardiac anomaly. We report a 25‐year‐old woman with LAAA presenting with atrial fibrillation and dyspnea. Multimodality imaging enabled diagnosis, and successful surgical resection was performed. Histopathology confirmed a benign aneurysm. At 6‐month follow‐up, no recurrence or thromboembolic events were observed.

Discussion

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Cite This Study

Parvizi et al. (2026) conducted a case report in Left atrial appendage aneurysm (LAAA) presenting with atrial fibrillation and exertional dyspnea (n=1). Complete surgical resection of left atrial appendage aneurysm via sternotomy, followed by warfarin and later catheter ablation was evaluated on Aneurysm exclusion, thromboembolic events, and arrhythmia recurrence.

synapsesocial.com/papers/6af9ebcdd393cbc380a04fe6 https://doi.org/10.1002/ccr3.73941

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Left Atrial Appendage Aneurysm Presenting With Atrial Fibrillation in a Young Woman: A Case Report

Figures

Key Points

Study Design

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Left Atrial Appendage Aneurysm Presenting With Atrial Fibrillation in a Young Woman: A Case Report

Figures

Key Points

Study Design

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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