January 17, 2017Open Access
View Full PaperEffects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic Hypertension
Structured PICO
Does sacubitril/valsartan reduce clinic and ambulatory central aortic and brachial pressures in elderly patients with systolic hypertension and stiff arteries compared to olmesartan?
P
Population
Elderly patients with systolic hypertension and stiff arteries
I
Intervention
Sacubitril/valsartan
C
Comparator
Olmesartan
O
Outcome
Clinic and ambulatory central aortic and brachial pressuressurrogate
Sacubitril/valsartan is superior to olmesartan in reducing central aortic and brachial pressures in elderly patients with systolic hypertension and stiff arteries.
Abstract
<0.002). Both treatments were equally well tolerated. The PARAMETER study (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Measuring Arterial Stiffness in the Elderly), for the first time, demonstrated superiority of sacubitril/valsartan versus olmesartan in reducing clinic and ambulatory central aortic and brachial pressures in elderly patients with systolic hypertension and stiff arteries.
Cite This Study
Williams et al. (Tue,) studied this question.