Supplementary Figure S2 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

• Mitochondrial APP improves antitumor immunity by preventing mitophagy in aging T-cells.
• ATAD3 shuttles CerS6 to mitochondria, impacted by the amyloid-β precursor protein.
• Mitochondrial APP's role in fumarate depletion highlights its importance in immune response.
• Understanding these mechanisms may lead to improved therapies targeting aging and immunity.