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July 11, 2024Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

FOXC1 and FOXC2 Ablation Causes Abnormal Valvular Endothelial Cell Junctions and Lymphatic Vessel Formation in Myxomatous Mitral Valve Degeneration

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CTCan TanZGZhi‐Dong GeSKS Kurup

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Tan et al. (2024) studied this question.

synapsesocial.com/papers/68e609bdb6db64358759ce34https://doi.org/10.1161/atvbaha.124.320316
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FOXC1 Controls Smooth Muscle Cell Differentiation and Plasticity in Vascular Disease2026
  2. 2PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves2023 · 18 citations
  3. 3PROX1 inhibits PDGF-B expression to prevent myxomatous degeneration of heart valves2023 · 2 citations
  4. 4Lymphatic dysfunction and ZFP36 deficiency contribute to myxomatous valve degeneration in Marfan Syndrome mice2026 · 1 citations
  5. 5Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease2016 · 61 citations