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October 9, 2025Journal of NeurophysiologyOpen Access

Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents

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Authors

TDTeresa DarceyJHJustin Shane HooperSNSanjay S. Nair

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Overview

Observational analysis shows specific inhaled activators induce changes in respiration and heart rate, suggesting distinct roles of vagal afferent subsets.

Key Points

  • Inhaled activators like capsaicin and AITC significantly affect respiration and heart rate in conscious mice.
  • Activation of TRPV1 and AITC leads to bradypnea and greater bradycardia, highlighting their distinct physiological roles.
  • Chemogenetic activation of specific airway afferent subsets reveals differing effects on cardiorespiratory function.
  • Data indicates that diverse vagal nociceptors play unique roles in regulating respiratory and cardiovascular responses.

Cite This Study

Darcey et al. (2025) studied this question.

synapsesocial.com/papers/68e8439a9989581a2fd4dfc4https://doi.org/10.1152/jn.00248.2025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding the role of genetically-distinct sensory nerves in controlling cardiopulmonary reflexes2024
  2. 2Anatomical and functional mapping of nociceptive sensory nerves innervating the lower airways2026
  3. 3Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics2025
  4. 4Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin, and ATP in Sprague-Dawley rats2015 · 30 citations
  5. 5Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats2018 · 17 citations