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March 16, 2026Integrated Environmental Assessment and ManagementOpen Access

The Fathead minnow Extended One Generation Reproduction Test (FEOGRT): A design for regulatory application

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Authors

GPGrace H. PanterRBRick BrownJWJeffrey C. Wolf

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Overview

This design assesses reproductive and endocrine toxicity in fish, suggesting a robust regulatory approach.

Key Points

  • The aim is to evaluate the Fathead minnow Extended One Generation Reproduction Test (FEOGRT) as a regulatory tool for assessing toxicity.
  • Comparison of FEOGRT with existing tests like MEOGRT and ZEOGRT
  • Evaluation of key life stages across three generations
  • Incorporation of endpoints such as vitellogenin and gonadal histopathology
  • FEOGRT is longer in duration than MEOGRT but offers advantages in test reliability and data availability
  • It requires fewer fish compared to other extended one generation tests
  • The design is based on established guidelines, easing validation processes.

Cite This Study

Panter et al. (2026) studied this question.

synapsesocial.com/papers/69b79e968166e15b153ac272https://doi.org/10.1093/inteam/vjag039
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Is seven days enough? Comparing a 7-day exposure to the classical 21-day OECD TG 229 fish short-term reproduction assay in fathead minnow2024
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  3. 3Biotechnological metabolization system has the potential to improve the predictive ability of the fish embryo acute toxicity (FET) test with the zebrafish (Danio rerio)2024 · 5 citations
  4. 4Comparative analysis of fish embryo acute toxicity (FET) test, fish cell line acute toxicity test and acute fish toxicity test: Evaluating the applicability domain of the FET test2026
  5. 5Examination of the reproductive effects of fluorine-free foam alternative exposure on fathead minnows ( <i>Pimephales promelas</i> )2026 · 2 citations