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March 16, 2026Integrated Environmental Assessment and ManagementOpen Access

The Fathead minnow Extended One Generation Reproduction Test (FEOGRT): A design for regulatory application

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Authors

GPGrace H. PanterRBRick BrownJWJeffrey C. Wolf

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Overview

This design assesses reproductive and endocrine toxicity in fish, suggesting a robust regulatory approach.

Key Points

  • The aim is to evaluate the Fathead minnow Extended One Generation Reproduction Test (FEOGRT) as a regulatory tool for assessing toxicity.
  • Comparison of FEOGRT with existing tests like MEOGRT and ZEOGRT
  • Evaluation of key life stages across three generations
  • Incorporation of endpoints such as vitellogenin and gonadal histopathology
  • FEOGRT is longer in duration than MEOGRT but offers advantages in test reliability and data availability
  • It requires fewer fish compared to other extended one generation tests
  • The design is based on established guidelines, easing validation processes.

Cite This Study

Panter et al. (2026) studied this question.

synapsesocial.com/papers/69b79e968166e15b153ac272https://doi.org/10.1093/inteam/vjag039
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