Population
Langendorff perfused C57/BL6 mouse hearts
Comparison
Isovolumic ventricular balloon model with 10-30… vs Apicobasal displacement model
Design
Preclinical
Follow-up
40 min reperfusion
Key result
The buffer perfused isovolumically contracting mouse heart model is more reliable and yields higher post-ischaemic recoveries than the apicobasal model.
Authors
Loading...
The isovolumic model offers superior reliability for mouse ischemia experiments; challenges apicobasal use and leaves open human translation.
Absolute Event Rate: 82% vs 80%
The buffer perfused isovolumically contracting mouse heart model is more reliable in assessing ischemic responses than the commonly employed apicobasal model.
Headrick et al. (2001) studied Myocardial ischaemia and reperfusion. Isovolumic ventricular balloon model vs. Apicobasal displacement model was evaluated on Post-ischaemic recovery of developed pressure after 10 min ischaemia. The buffer perfused isovolumically contracting mouse heart model is more reliable and yields higher post-ischaemic recoveries than the apicobasal model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: