Why the study?
Existing data regarding the incidence and timing of post-myocardial infarction heart failure showed inconsistencies, despite modern PCI and guideline-directed medical therapy.
Population
384,145 patients with a first AMI in Sweden
Comparison
HF onset at 0–3 months vs 4–12 months vs no post-MI HF
Design
Nationwide retrospective observational register-based cohort study
Follow-up
Within 2 years post-MI
Key result
Incident heart failure within 0-3 months post-myocardial infarction was associated with a significantly higher risk of 2-year mortality compared to no heart failure (HR 2.05; 95% CI 2.02-2.08; P<0.0001).
Authors
Loading...
Provides contemporary post-MI HF incidence and timing data; leaves open targeted prevention strategies for prospective trials.
Cohort (n=384,145)
Yes
Hazard Ratio: 2.05 (95% CI 2.02–2.08)
p-value: p=< 0.0001
Heart failure remains a prevalent and highly prognostic complication within the first year after a first myocardial infarction, significantly increasing the risk of mortality within 2 years.
Fu et al. (2025) conducted a cohort in Acute myocardial infarction (n=384,145). Incident heart failure post-MI vs. No incident heart failure post-MI was evaluated on All-cause mortality within 2 years post-MI (HR 2.05, 95% CI 2.02-2.08, p=< 0.0001). Incident heart failure within 0-3 months post-myocardial infarction was associated with a significantly higher risk of 2-year mortality compared to no heart failure (HR 2.05; 95% CI 2.02-2.08; P<0.0001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: