Supplementary Figure S3 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Key Points

• Induction of ferroptosis was observed in DLBCL cells treated with Zotatifin, indicating a novel therapeutic strategy.
• Key metrics involved BODIPY oxidation assessments and GSH/GSSG ratios, showing significant oxidative stress induction.
• Assessment using MitoSOX and DHE staining provided clear evidence of mitochondrial and cellular oxidative stress levels.
• Findings may highlight the potential for combining NRF2 inhibition with CAR T-cell immunotherapy for better responses.