Journal of Cardiac FailureKaur et al.cohort
CICU patients with DPP3 >30 ng/mL had higher in-hospital mortality.
DPP3 >30 ng/mL should not yet guide CICU decisions; hypothesis-generating for its prognostic utility in cardiovascular critical illness.
GK
Gurleen Kaur
Lipoproteins and Cardiovascular Health
Brigham and Women's Hospital
About
Research focus
Lipoproteins and Cardiovascular Health
Impact
184 pubs · 1,485 cites · h-index 23
Affiliations
Publications
Journal of Vascular DiseasesGrover et al.cross-sectional
US primary pulmonary hypertension mortality drops ~44% from 2018 to 2024 despite persistent demographic disparities.
Observed decline in I27.0 deaths may reflect care or coding shifts; extends surveillance but leaves causal factors open.
NeurologyMahim et al.Original Research
Focal Status Epilepticus Masquerading as Stroke in Diabetic Ketoacidosis: A Diagnostic Challenge (P5-11.003)
Case report illustrates focal status epilepticus presenting as stroke in diabetic ketoacidosis, highlighting diagnostic difficulties.
Ankeet S. Bhatt
Heart Failure / Cardiomyopathy · Brigham and Women's Hospital
To see that a virtual care team could help improve guideline-concordant care across three diverse system hospitals and do so in a manner that was both safe and did not prolong hospitalization was a very encouraging finding.
Virtual Care Team Guided Management of Patients With Heart Failure During Hospitalization
Journal of the American College of CardiologyBhatt et al.
Medical Journal of Dr D Y Patil VidyapeethSingh et al.Original Research
Salmonella in Throat: This is Highly Unexpected
Case report describes an unusual instance of tonsillitis caused by Salmonella in a young male, suggesting rare pathogen behavior.
JACCBerman et al.cohort
Top-decile Lp(a) linked to ~93% higher major cardiovascular events risk in primary prevention.
Elevated Lp(a) is independently associated with long-term MACE in both primary and secondary prevention cohorts, though the risk threshold may differ between these groups.
EuroInterventionKaur et al.review
Review summarizes current evidence on oral and novel parenteral antiplatelet pretreatment in CAD.
Antiplatelet pretreatment in CAD warrants cautious individualized use in PCI; leaves open optimal regimens pending dedicated trials.
CureusKaur et al.Case Report
Sturge-Weber Syndrome With Leptomeningeal Angiomatosis and Middle Cerebral Artery Narrowing Treated With Intravenous Tissue Plasminogen Activator (IV tPA): A Case Report
Case report finds safe use of IV tPA for stroke in a patient with Sturge-Weber syndrome, indicating treatment viability.
Akturk et al.cohort
Adjunctive tirzepatide linked to improved CGM metrics in overweight T1D adults without increasing hypoglycemia risk.
Supports adjunctive tirzepatide in overweight adults with T1D; extends evidence but hypothesis-generating pending RCTs.
Journal of AgrometeorologyKaur et al.Original Research
Heat use efficiency and yield optimization in wheat as influenced by irrigation scheduling
Field study demonstrates that irrigation scheduling improves grain yield in wheat, highlighting resource use efficiency.
Deleted JournalJeet et al.Observational Study
Are Practicing Physiotherapists Physically Fit? An Observational Study on Fitness during Direct Clinical Care
Observational study reveals low physical fitness levels in physiotherapists, indicating potential health risks.
Singh et al.Narrative Review
Cannabis Hyperemesis or Cyclic Vomiting- A Comparative Literature Review
Literature review identifies overlapping symptoms and treatment challenges in cannabis hyperemesis and cyclic vomiting syndrome.
International Journal of Case Reports and ImagesSingh et al.Case Report
Antibodies everywhere: The spectrum of IgG4-related disease—A case series and literature review
Introduction: IgG4-related disease (RD) is now known to affect multiple organs, including the gastrointestinal system, kidneys, lungs, and retroperitoneum. Diagnosis of IgG4-RD involves a combination of clinical, radiological, serological, and histopathological findings. Case Series: This case series underscores the importance of recognizing IgG4-RD as a potential etiology of diseases of unclear pathology with patient presentations, including pancreatitis, cholangitis, renal and mesenteric ischemia, back mass, and interstitial lung disease. Conclusion: Further, we discuss the histological findings, imaging, serology, other organ involvement and response therapy (HISORt) criterion of diagnosis, and treatment options including steroid-sparing agents.
Medical ReportsSingh et al.Guideline
Catch me if you can- Hereditary hemorrhagic telangiectasia presenting as gastrointestinal bleed!
Background Hereditary hemorrhagic telangiectasia (HHT) is a rare, autosomal dominant genetic disorder. It produces abnormal vasculature throughout the body, contributing to varying bleeding manifestations. Similarly, gastrointestinal involvement can result from arteriovenous malformations (AVM), which can spontaneously bleed, presenting as iron deficiency anemia. Aim/Objective Recognizing patterns that can indicate HHT, using appropriate diagnostic criteria, and learning guideline-directed management. Case A 61-year-old female presenting with treatment-resistant iron deficiency anemia was evaluated with endoscopy, which revealed a duodenal AVM. The patient underwent a CT scan for lung cancer screening, revealing multiple bilateral pulmonary AVMs. This led to a suspicion of HHT. A push enteroscopy was pursued, revealing 40 bleeding AVMs. Discussion HHT can present with cerebral, pulmonary, gastrointestinal, and hepatic involvement with fatal complications. Diagnostic criteria and genetic testing can be utilized for the diagnosis, and further screening helps reduce mortality. Even in cases of late presentation, patients should be referred to and established with appropriate sub-specialists to monitor complications. Recognizing HHT as a potential cause of otherwise unexplained gastrointestinal bleeding is crucial for prompt diagnosis and timely intervention to prevent serious complications.
Asian Journal of Pharmaceutical and Clinical ResearchPatra et al.RCT
Impact of Physical Therapy Approach in Subjects With Post-Dengue Fatigue Syndrome
Objectives: The objective of the study was to study the effectiveness of an innovative exercise regimen in alleviating fatigue and enhancing health-related quality-of-life (HRQoL) in individuals suffering from post-dengue fatigue syndrome (PDFS). Methods: A randomized controlled trial was conducted, with participants diagnosed with PDFS. The innovative exercise protocol included aerobic exercises, graded exercises, breathing exercises, emotional liberation-breathing, Jacobson exercises, and psycho-neurobics, administered over a 6-week period. Both groups received face-to-face and online interaction and video calls for guidance. The outcome measures were the fatigue severity scale (FSS) and HRQoL, assessed before and after the intervention. Results: The 6-week rehabilitation program led to significant improvements in both groups, as reflected by reduced fatigue levels, evaluated using the FSS, and enhanced HRQoL components. Notably, the experimental group exhibited more significant improvements in reducing fatigue and six HRQoL components, although no significant improvements were observed in surface fitting and grasshopper components. The innovative exercise protocol, alongside the home-based exercise regimen, demonstrated statistically significant effects on alleviating fatigue and improving HRQoL in PDFS patients. Conclusion: This research underscores the potential of exercise interventions in managing PDFS, shedding light on the beneficial impact of innovative exercise routines on fatigue and HRQoL in individuals dealing with PDFS. Nonetheless, tailored approaches may be necessary to target specific components of HRQoL, such as social functioning and general health, warranting further investigation in this domain.
Cardiology in ReviewBiswas et al.meta-analysis
Enhanced external counterpulsation (EECP) reduced systolic blood pressure in hypertensive patients.
EECP therapy significantly reduces both systolic and diastolic blood pressure in hypertensive patients, suggesting its potential as an effective noninvasive adjunctive treatment.
SHILAP Revista de lepidopterologíaKaur et al.cohort
Elevated lipoprotein(a) is associated with fatal or nonfatal myocardial infarction in women and men.
Extends Lp(a)-MI link to primary prevention without prior ASCVD; leaves open whether lowering Lp(a) reduces events.
Diabetes Technology & TherapeuticsGarg et al.cohort
Off-label tirzepatide shows no reported cardiorenal biomarker effects in type 1 diabetes.
Introduction: Overweight (OW) and obesity (OB) affect nearly two thirds of adults with type 1 diabetes (T1D), contributing to suboptimal glucose control, cardiovascular disease (CVD), and diabetic kidney disease (DKD). Many newer drugs such as tirzepatide (a dual-incretin) and sodium–glucose cotransporter-2 inhibitors are approved for people with type 2 diabetes associated with CVD and DKD. We evaluated CVD and DKD biomarkers with off-label long-term (21 months) use of tirzepatide in OW/OB adults with T1D.
US Cardiology ReviewKaur et al.Original Research
Navigating Digital Medical Education in the Current Era: Process Over Platform
With the dawn of advanced technological and digital resources, medical education has changed. Learners are now able to learn, share, and communicate medical knowledge through online discussion forums, blogs, videos, podcasts, infographics, virtual communities, social media platforms, and collaborative author groups. Navigating these digital education modalities can be challenging, with each platform presenting unique challenges and opportunities. Digital educators need to learn how to navigate this uncertain territory, equipped with a skillset applicable to all digital spaces. This article explores the key components of a digital educator's skillset by examining the core foundations of learning theory, creation of digital education materials, and virtual communities of practice.
Diabetes Technology & TherapeuticsSnell‐Bergeon et al.Retrospective Study
Effectiveness of Semaglutide and Tirzepatide in Overweight and Obese Adults with Type 1 Diabetes
Objective: Adults with type 1 diabetes (T1D) are increasingly overweight or obese, in part due to intensive insulin therapy. Newer non-insulin medications targeting both hyperglycemia and weight loss are approved for people with type 2 diabetes. These drugs also reduce cardiovascular disease, the major cause of mortality in people with diabetes. We assessed the real-world use of semaglutide and tirzepatide, in adults with T1D followed in a specialty diabetes clinic. Materials and Methods: This retrospective chart review included 100 adults who were prescribed semaglutide or tirzepatide (50 each) and 50 controls frequency matched for age, sex, diabetes duration, body mass index, and glycosylated hemoglobin (HbA1c) and who did not receive any weight loss medications during the study period. Data were collected prior to initiation of weight loss medications (baseline) and then for up to 1 year for each patient. Results: Matching characteristics did not differ between cases and controls. There were declines in weight in both semaglutide (-19.2 ± standard error (SE) 2.9 lbs. [9.1% body weight lost]) and tirzepatide (-49.4 ± SE 3.0 lbs. [21.4% body weight lost]) groups, and HbA1c decreased in both semaglutide (-0.54 ± SE 0.14%, P = 0.0001) and tirzepatide users (-0.68 ± SE 0.16%, P < 0.0001) over 12 months. Weight and HbA1c didn't change in controls. Conclusions: We observed weight loss of 9.1% and 21.4% and improved glucose control in semaglutide and tirzepatide users, respectively, after 1 year of off-label use. As off-label use of these drugs is increasing in patients with T1D, larger, prospective safety and efficacy trials are needed.