Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Key Points

• Apolipoprotein E influences the remodeling of the tumor-stroma ratio in pancreatic neuroendocrine tumors.
• Endothelial cells utilize lipid metabolism for recruiting fibroblasts, supporting tumor progression.
• The study highlights a unique interaction between apolipoprotein E and endothelial cells within the tumor microenvironment.
• Understanding this mechanism could lead to new strategies for targeting cancer progression in pancreatic neuroendocrine tumors.