Figure S14 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• mTOR inhibition initiates both ferritinophagy and ferroptosis in head and neck cancer, enhancing treatment options.
• The study shows that combining mTOR inhibitors with auranofin leads to increased efficacy, indicating synergistic effects.
• Using genome-wide CRISPR screening, the analysis identifies critical pathways involved in cancer progression and response to treatment.
• These findings highlight the importance of targeting mTOR pathways, which may improve treatment strategies for HNSCC patients.