Supplementary Figure S1 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Key Points

• Inhibition of nrf2 translation sensitizes lymphoma cells to ferroptosis, leading to improved treatment outcomes.
• Transcriptomic analysis showed altered gene expression and enriched pathways in zotatifin-treated DLBCL cells.
• Using methods like RNA-seq, the study highlights the role of NF-κB signaling in response to therapy.
• Findings suggest that targeting nrf2 may be a strategic approach to enhancing CAR T-cell immunotherapy effects.