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June 12, 2014AJP Cell Physiology

Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart

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Why the study?

Does STZ-induced type 1 diabetes alter mitochondrial bioenergetics and ATP synthesis in rat heart tissues?

Population

Sprague-Dawley rats

Comparison

Streptozotocin injection to induce type 1… vs Equivalent volume of saline injection, followed…

Design

Preclinical

Follow-up

8 weeks

Authors

TPToan PhamDLDenis S. LoiselleAPAmelia Power

Discussion

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Overview

Mitochondrial inefficiencies may contribute to diabetic cardiomyopathy in rat models; leaves open relevance to human type 1 diabetes.

Structured PICO

Does STZ-induced type 1 diabetes alter mitochondrial bioenergetics and ATP synthesis in rat heart tissues?

P
Population
Sprague-Dawley rats
I
Intervention
Streptozotocin (STZ, 55 mg/kg) injection to induce type 1 diabetes, followed by 8 weeks of standard rat chow
C
Comparator
Equivalent volume of saline injection (control, n=12), followed by 8 weeks of standard rat chow
O
Outcome
Mitochondrial bioenergetics including oxygen flux linked to steady-state ATP synthesis, reactive oxygen species (ROS) production, and mitochondrial membrane potential (ΔΨ)surrogate

Diabetic rat hearts exhibit significant mitochondrial bioenergetic inefficiencies, including depressed ATP synthesis and increased ROS production during oxidative phosphorylation, which may contribute to diabetic cardiomyopathy.

Cite This Study

Pham et al. (2014) studied this question.

synapsesocial.com/papers/6a1cd3b4c1a6f558a750b6abhttps://doi.org/10.1152/ajpcell.00006.2014
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial Respiratory Impairment in Streptozotocin-Induced Diabetic Rat Heart1996 · 66 citations
  2. 2Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart1996 · 170 citations
  3. 3The effect of diabetes on performance and metabolism of rat hearts.1980 · 255 citations
  4. 4Mitochondrial dysfunction observed in situ in cardiomyocytes of rats in experimental diabetes1992 · 89 citations
  5. 5Impaired contractile function and mitochondrial respiratory capacity in response to oxygen deprivation in a rat model of pre‐diabetes2009 · 26 citations