Supplementary Figure S7 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Key Points

• Blocking nrf2 translation increases sensitivity of lymphoma cells to ferroptosis and T-cell immunotherapy, enhancing treatment effects.
• Key evidence shows treatments with zotatifin and IKE significantly activate cleaved caspase in lymphoma, indicating apoptosis.
• The analysis included tumor imaging and immunohistochemistry assessments focusing on cleaved caspases and lipid peroxidation.
• These findings highlight the potential for combining nrf2 inhibition with existing lymphoma therapies for improved patient outcomes.