Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Key Points

• Blocking nrf2 translation increases sensitivity to ferroptosis in lymphoma cells, leading to improved treatment outcomes.
• The study shows that rocaglates inhibit nrf2 translation via cap-dependent initiation, backed by multiple assays.
• Immunoblots and luciferase assays demonstrate the efficacy of rocaglates in reducing nrf2 levels in cancer cells.
• By sensitizing lymphoma cells to ferroptosis, this approach may enhance the effectiveness of car t-cell immunotherapy.