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August 6, 2025Open Access

High interleukin-8 serum levels independently predict long-term all-cause mortality in chronic heart failure

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Authors

JTJan TraubMSMichael K. SchuhmannUHUlrich Hofmann

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Overview

High interleukin-8 levels predict all-cause mortality in chronic heart failure patients, suggesting inflammation's role in disease progression.

Key Points

  • High interleukin-8 serum levels were independently associated with increased risk of all-cause mortality in chronic heart failure patients.
  • Patients with IL-8 levels over 5.3 pg/ml had an Adjusted Hazard Ratio of 2.57 for mortality, indicating substantial risk.
  • The study tracked survival data over 10 years, with comprehensive evaluations of clinical and cognitive health.
  • Findings highlight interleukin-8's potential as a biomarker and therapeutic target for managing chronic heart failure.

Cite This Study

Traub et al. (2025) studied this question.

synapsesocial.com/papers/689523d29f4f1c896c429fbahttps://doi.org/10.1101/2025.08.03.25332911
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Also Consider

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  1. 1High interleukin-8 serum levels independently predict long-term all-cause mortality in chronic heart failure2025 · 4 citations
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  4. 4Soluble interleukin-2 receptor combined with interleukin-8 is a powerful predictor of future adverse cardiovascular events in patients with acute myocardial infarction2023 · 15 citations
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