Why the study?
Inflammation is increasingly recognized in chronic heart failure progression, but the association of cytokine and chemokine profiles with mild cognitive impairment and long-term mortality required investigation.
Do high interleukin-8 serum levels predict all-cause mortality and mild cognitive impairment in patients with chronic heart failure?
Population
145 patients with chronic HF from the Cognition.Matters-HF baseline cohort
Comparison
Cytokine and chemokine profiles, including high vs lower IL-8 levels
Design
Cohort study
Follow-up
10 years
Key result
High interleukin-8 serum levels (>5.3 pg/ml) independently predicted a 2.57-fold increased risk of 10-year all-cause mortality in patients with chronic heart failure.
Authors
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May refine risk stratification in chronic HF; hypothesis-generating for IL-8 as therapeutic target.
Cohort (n=145)
No
Do high interleukin-8 serum levels predict all-cause mortality and mild cognitive impairment in patients with chronic heart failure?
Hazard Ratio: 2.57 (95% CI 1.44–4.57)
p-value: p=0.001
High serum IL-8 levels independently predict long-term all-cause mortality in patients with chronic heart failure, suggesting its potential as a prognostic biomarker.
Traub et al. (2025) conducted a cohort in Chronic heart failure (n=145). High interleukin-8 (IL-8) serum levels (>5.3 pg/ml) vs. IL-8 levels ≤ 5.3 pg/ml was evaluated on 10-year all-cause mortality (Adj. HR 2.57, 95% CI 1.44-4.57, p=0.001). High interleukin-8 serum levels (>5.3 pg/ml) independently predicted a 2.57-fold increased risk of 10-year all-cause mortality in patients with chronic heart failure.
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