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July 12, 2025Journal of Orthopaedic Surgery and ResearchOpen Access

Effectiveness of anabolic and anti-resorptive agents for preventing postmenopausal osteoporosis fractures: a systematic review and network meta-analysis

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Authors

PSPeng SuMLMaofu LiJXJian Xiao

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Overview

Systematic review and network meta-analysis reveals anabolic agents boost bone density in postmenopausal women, implying optimal cycling strategies are needed for fracture prevention.

Key Points

  • ANALYSIS SHOWS: Anti-sclerostin antibody is the most effective anabolic agent for increasing bone mineral density and reducing fracture risk.
  • SIGNIFICANT EVIDENCE: Anti-RANKL antibody enhances bone density over 36 months while maintaining similar discontinuation rates as placebo.
  • RESEARCH METHOD: Network meta-analysis of 227 trials with over 140,000 participants assessed various anabolic and anti-resorptive therapies.
  • CLINICAL IMPACT: Findings may guide treatment strategies for osteoporosis in high-risk postmenopausal populations, enhancing patient outcomes.

Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbed3https://doi.org/10.1186/s13018-025-06040-3
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