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May 2, 2024NeurospineOpen Access

Comparison of the Clinical Efficacy of Anabolic Agents and Bisphosphonates in the Patients With Osteoporotic Vertebral Fracture: Systematic Review and Meta-analysis of Randomized Controlled Trials

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Authors

IJIkchan JeonYeungnam University Medical CenterSPSung Bae ParkSeoul National UniversityBMBong Ju MoonYonsei University

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Implication

Systematic review and meta-analysis of randomized controlled trials demonstrates lower new fracture rates with anabolic agents in vertebral fracture patients, highlighting bone-building benefits.

Key Points

  • Anabolic agents significantly reduce the incidence of new osteoporotic vertebral fracture compared with bisphosphonates in patients with osteoporotic vertebral fracture.
  • A relative risk of 0.57 shows anabolic agents reduce new fractures, while fracture healing shows no significant benefit with a relative risk of 1.23.
  • Systematic review and meta-analysis of randomized controlled trials supports anabolic efficacy, yet highlights the need for larger trials to confirm healing.

Cite This Study

Jeon et al. (2024) studied this question.

synapsesocial.com/papers/68e6bbe0b6db64358763cb45https://doi.org/10.14245/ns.2347256.628
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