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July 14, 2025

Computational Assessment of Substituted 2-Mercaptobenzimidazole Schiff Bases Derivatives Targeting α-Amylase, α-Glucosidase, and PPAR-γ Receptor in Type 2 Diabetes Mellitus

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Authors

VPV. S. PatilSKS.P. KokaneGDGajanan Ganesh Deshmane

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Overview

Computational docking reveals promising multi-target Schiff bases for reducing postprandial glucose in type 2 diabetes, indicating their potential as antidiabetic agents.

Key Points

  • The study examines substituted 2-mercaptobenzimidazole Schiff bases targeting α-amylase and α-glucosidase in type 2 diabetes.
  • Molecular docking identified several compounds with stronger binding energies than the reference drug acarbose.
  • Key interactions involved hydrogen bonds and hydrophobic contacts with important amino acids of the target enzymes.
  • These findings support the potential of Schiff bases as multi-target agents for new antidiabetic therapies.

Cite This Study

Patil et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cc114https://doi.org/10.21203/rs.3.rs-6892367/v1
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