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July 14, 2025

Stage IA and IC Adult Granulosa Cell Tumors: Clinical Features, Long-Term Outcomes and Prognostic Factors in a 333-Patient Cohort Over Three Decades

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Authors

JGJingwen GanChinese Academy of Medical Sciences & Peking Union Medical CollegeXMXiao MaShanghai Institute of Quality Inspection and Technical ResearchYCYing CaoSichuan University

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Implication

Retrospective cohort study showed recurrence rates differ in stage I adult granulosa cell tumors, indicating surgical staging impacts outcomes.

Key Points

  • Stage IC adult granulosa cell tumors had significantly higher recurrence rates at 59.1% compared to stage IA, which was 40.9%.
  • Multivariate logistic regression identified stage IC and adjuvant chemotherapy as significant negative predictors for recurrence.
  • This 30-year retrospective study analyzed 333 patients with stage I adult granulosa cell tumors from 1988 to 2024.
  • Comprehensive surgical staging without lymphadenectomy is recommended for stage IC patients to improve disease-free survival rates.

Cite This Study

Gan et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cc151https://doi.org/10.21203/rs.3.rs-6987381/v1
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