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March 23, 2026Journal of CancerOpen Access

Recurrence of Adult Granulosa Cell Tumors: The Factors Affecting Secondary Recurrence and Survival After Recurrence

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Authors

HEHasan Volkan EgeMemorial Ankara HospitalDBDerman BaşaranMGMurat GultekinHacettepe University

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Implication

This multicenter retrospective study identifies factors impacting secondary recurrence and survival in recurrent granulosa cell tumors, suggesting management strategies.

Key Points

  • This research aims to identify factors associated with secondary recurrence and survival after recurrence in adult-type granulosa cell tumors (AGCTs).
  • Multicenter retrospective analysis of 52 patients with recurrent AGCTs from 2000 to 2023.
  • Evaluation of clinical characteristics, treatment modalities, and their outcomes.
  • Kaplan-Meier analysis used to assess recurrence-free survival and overall survival after first recurrence.
  • Secondary recurrence observed in 32.7% of patients (17 out of 52).
  • Elevated serum CA-125 levels (>35 U/mL) at first recurrence significantly linked to higher risk of secondary recurrence (p=0.01).
  • Factors enhancing overall survival after first recurrence included lower CA-125 levels and absence of residual disease post-surgery.

Cite This Study

Ege et al. (2026) studied this question.

synapsesocial.com/papers/69c0ddb8fddb9876e79c111chttps://doi.org/10.7150/jca.127596
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Also Consider

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  5. 5Ten-Year Real-World Outcomes and Clinicopathologic Predictors of Recurrence in Adult Granulosa Cell Tumors: A Turkish Single-Center Experience2025