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July 15, 2025Frontiers in NeuroscienceOpen Access

Modulating excitation/inhibition balance through transcranial electrical stimulation: physiological mechanisms in animal models

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Authors

MEMarta Estévez-RodríguezGCGuillermo Sánchez-Garrido CamposÁZÁngela M. Zafra

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Overview

Animal models reveal how transcranial electrical stimulation affects excitation/inhibition balance, suggesting new approaches for brain disorders.

Key Points

  • MAIN FINDING: Transcranial electrical stimulation effectively modulates the excitation/inhibition balance in neural circuits.
  • KEY EVIDENCE: Research shows that different tES modalities influence synaptic plasticity and neuronal excitability in distinct ways.
  • APPROACH: Animal models were used to explore the effects of transcranial direct current stimulation, alternation, and noise on E/I regulation.
  • SIGNIFICANCE: These insights can inform personalized neuromodulation strategies to address neurological disorders like epilepsy and schizophrenia.

Cite This Study

Estévez-Rodríguez et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc5c2https://doi.org/10.3389/fnins.2025.1609679
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