What question did this study set out to answer?

To establish and validate a standardized protocol for administering noninvasive transcranial electrical stimulation across an intact skull in alert, behaving rodents.

November 2, 2017Journal of Visualized ExperimentsOpen Access

Transcranial Electrical Brain Stimulation in Alert Rodents

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Authors

BFBrita Fritsch AGAnne‐Kathrin Gellner JRJanine Reis

Discussion

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Overview

Methodological study demonstrates a noninvasive transcranial electrical stimulation protocol in alert rodents, highlighting a translatable platform for mechanistic and safety investigations.

Key Points

To establish and validate a standardized protocol for administering noninvasive transcranial electrical stimulation across an intact skull in alert, behaving rodents.
Designed a surgical protocol establishing a permanent epicranial electrode socket over the motor cortex paired with an implanted counter electrode on the rodent chest.
Configured the apparatus to deliver direct current (tDCS), alternating current (tACS), or random noise stimulation (tRNS) across adjustable current densities and durations in awake animals.
Achieved stable delivery of diverse electrical stimulation waveforms through the intact skull without requiring general anesthesia.
Provided practical guidelines for managing tolerability, current density thresholds, and electrode socket integrity during repeated stimulation sessions.

Cite This Study

Fritsch et al. (2017) studied this question.

synapsesocial.com/papers/6aab38e366346469fda534c8 https://doi.org/10.3791/56242

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November 2, 2017Journal of Visualized ExperimentsOpen Access

Transcranial Electrical Brain Stimulation in Alert Rodents

View Full Paper

Ask AI

Bookmark

Authors

BFBrita Fritsch AGAnne‐Kathrin Gellner JRJanine Reis

Discussion

Member takes

Overview

Methodological study demonstrates a noninvasive transcranial electrical stimulation protocol in alert rodents, highlighting a translatable platform for mechanistic and safety investigations.

Key Points

To establish and validate a standardized protocol for administering noninvasive transcranial electrical stimulation across an intact skull in alert, behaving rodents.
Designed a surgical protocol establishing a permanent epicranial electrode socket over the motor cortex paired with an implanted counter electrode on the rodent chest.
Configured the apparatus to deliver direct current (tDCS), alternating current (tACS), or random noise stimulation (tRNS) across adjustable current densities and durations in awake animals.
Achieved stable delivery of diverse electrical stimulation waveforms through the intact skull without requiring general anesthesia.
Provided practical guidelines for managing tolerability, current density thresholds, and electrode socket integrity during repeated stimulation sessions.

Cite This Study

Fritsch et al. (2017) studied this question.

synapsesocial.com/papers/6aab38e366346469fda534c8 https://doi.org/10.3791/56242

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