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July 15, 2025Open Access

Metal stress uncouples early pre-rRNA processing from ISR activation and reveals flexible checkpoints in human ribosome biogenesis

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Authors

AAAnne AldrichRTRachael J. ThomasMBMichael D. Blower

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Overview

Research reveals that metal stress uncouples pre-rRNA processing from endoplasmic reticulum stress, indicating new regulation in ribosome assembly.

Key Points

  • Ribosome synthesis is highly energy-intensive, consuming over 60% of cellular energy.
  • Early pre-rRNA processing is particularly sensitive to heavy metal stress, leading to uncoupled processing stages.
  • Stress from heavy metals leads to reduced ribosomal protein synthesis while rRNA transcription remains intact.
  • Findings highlight new regulatory checkpoints in ribosome biogenesis that impact cellular stress and proteostasis.

Cite This Study

Aldrich et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc5cahttps://doi.org/10.1101/2025.07.14.664728
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